Quarterly guidance

Quarterly guidance
No specific quarterly guidance was given.

Annual guidance

GAAP operating expenses
$2.1 billion to $2.2 billion for full year 2026, including $270 million to $290 million of stock-based compensation.

Outlook

Operating expenses
Full year 2027 GAAP operating expenses are expected to increase from the current GAAP operating expense run rate due to expanded investments in the RAS(ON) inhibitor portfolio and global commercial infrastructure.
Gross to net discount
Expected to increase within the anticipated 20% to 30% range as payer mix and discounts mature.
Channel inventory
Expected to be managed at approximately 2 weeks over the long term.